The WHO currently recommends the following combination therapies (in alphabetical order) for the treatment of uncomplicated falciparum malaria:

- artemether/lumefantrine,
- artesunate plus amodiaquine(In areas where the cure rate of amodiaquine monotherapy is greater than 80%)

- artesunate plus mefloquine(Insufficient safety data to recommend its use in Africa)

- artesunate plus sulfadoxine/pyrimethamine(In areas where the cure rate of sulfadoxine/pyrimethamine is greater than 80%)

Note: Amodiaquine plus sulfadoxinepyrimethamine may be considered as an interim option where ACTs can not be made available, provided that efficacy of both is high.


For a better knowledge of all the guidelines of malaria treatment (complicated cases, malaria in children, others plasmodium species, etc.), we strongly recommend to you the document "Guidelines for the treatment of malaria of the W.H.O" (downloadable or printable)